Apple released the iTunes 12.8.1 update for OS X Yosemite to macOS High Sierra this week. This update fixes an issue that may prevent iTunes from pushing media to third-party AirPlay speakers and fixes other bugs. However, users who are still running OS X Yosemite 10.10.5 need to be careful not to upgrade iTunes 12.8.1. Many netizens found that upgrading iTunes 12.81.1 will cause Safari 10.1.2 to fail to open.
Some users believe that iTunes 12.8.1 may upgrade the System/Library/PrivateFrameworks/MobileDevice.framework, and the new framework is not compatible with Safari 10.1.2. Currently, we can use other browsers or wait for Apple updates.